In this paper we present the process of road noise simulation as an analytical tool for decision‐making in the conversion of radial to tranverse routes, designed for public transport in the city of Medellin. To obtain the existing noise pollution level and its subsequent comparison with the level from proposed redesign, a road map in the center of the city through the SoundPLAN software was carried out and various scenarios were predicted based on the analysis of decrease in the number of heavy vehicles in conflicting ways. Finally, air quality parameters, demand of passenger, travel time, and average speed were integrated in order to propose environmentally optimal routes and to improve mobility in the city.