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Structural Analysis of Glaucoma Brain and its Association with Ocular Parameters

dc.creatorGracitelli C.P.
dc.creatorDuque-Chica G.L.
dc.creatorSanches L.G.
dc.creatorMoura A.L.
dc.creatorNagy B.V.
dc.creatorTeixeira S.H.
dc.creatorAmaro E.
dc.creatorVentura D.F.
dc.creatorParanhos A.
dc.date2020
dc.date.accessioned2021-02-05T14:58:48Z
dc.date.available2021-02-05T14:58:48Z
dc.identifier.issn10570829
dc.identifier.urihttp://hdl.handle.net/11407/6020
dc.descriptionPurpose: To evaluate structural brain abnormalities in glaucoma patients using 3-Tesla magnetic resonance imaging and assess their correlation with associated structural and functional ocular findings. Patients and Methods: This cross-sectional prospective study included 30 glaucoma patients and 18 healthy volunteers. All participants underwent standard automated perimetry, spectral-domain optical coherence tomography, and 3.0-Tesla magnetic resonance imaging. Results: There was a significant difference between the surface area of the occipital pole in the left hemisphere of glaucoma patients (mean: 1253.9±149.3 mm2) and that of control subjects (mean: 1341.9±129.8 mm2), P=0.043. There was also a significant difference between the surface area of the occipital pole in the right hemisphere of glaucoma patients (mean: 1910.5±309.4 mm2) and that of control subjects (mean: 2089.1±164.2 mm2), P=0.029. There was no significant difference between the lingual, calcarine, superior frontal, and inferior frontal gyri of glaucoma patients and those of the control subjects (P>0.05 for all comparisons). The surface area of the occipital pole in the left hemisphere was significantly correlated with perimetry mean deviation values, visual acuity, age, and retinal nerve fiber layer thickness (P=0.001, P<0.001, P=0.010, P=0.006, respectively). The surface area of the occipital pole in the right hemisphere was significantly correlated with perimetry mean deviation values, visual field indices, visual acuity, age, and retinal nerve fiber layer thickness (P<0.001, P=0.007, P<0.001, P=0.046, P<0.001, respectively). Conclusions: Glaucoma patients presented a decreased occipital pole surface area in both hemispheres that independently correlated with functional and structural ocular parameters. Copyright © 2020 Wolters Kluwer Health, Inc.
dc.language.isoeng
dc.publisherLippincott Williams and Wilkins
dc.relation.isversionofhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85080029636&doi=10.1097%2fIJG.0000000000001470&partnerID=40&md5=606bbbf100289a0010e14e4651d237da
dc.sourceJournal of Glaucoma
dc.subject3-Teslaspa
dc.subjectglaucomaspa
dc.subjectmagnetic resonance imagingspa
dc.subjectoccipital polespa
dc.subjectvisual fieldspa
dc.titleStructural Analysis of Glaucoma Brain and its Association with Ocular Parameters
dc.typeArticleeng
dc.rights.accessrightsinfo:eu-repo/semantics/restrictedAccess
dc.publisher.programPsicologíaspa
dc.identifier.doi10.1097/IJG.0000000000001470
dc.publisher.facultyFacultad de Ciencias Sociales y Humanasspa
dc.affiliationGracitelli, C.P., Department of Ophthalmology and Visual Sciences, Paulista School of Medicine, São Paulo Hospital, Federal University of São Paulo, Brazil
dc.affiliationDuque-Chica, G.L., Institute of Psychology, University of São Paulo, São Paulo, Brazil, Department of Psychology, University of Medellin, Medellin, Colombia
dc.affiliationSanches, L.G., Hospital Israelita Albert Einstein, São Paulo, Brazil
dc.affiliationMoura, A.L., Department of Ophthalmology and Visual Sciences, Paulista School of Medicine, São Paulo Hospital, Federal University of São Paulo, Brazil, Institute of Psychology, University of São Paulo, São Paulo, Brazil
dc.affiliationNagy, B.V., Institute of Psychology, University of São Paulo, São Paulo, Brazil, Department of Mechatronics, Optics and Engineering Informatics, Budapest University of Technology and Economics, Budapest, Hungary
dc.affiliationTeixeira, S.H., Department of Ophthalmology and Visual Sciences, Paulista School of Medicine, São Paulo Hospital, Federal University of São Paulo, Brazil
dc.affiliationAmaro, E., Hospital Israelita Albert Einstein, São Paulo, Brazil
dc.affiliationVentura, D.F., Department of Ophthalmology and Visual Sciences, Paulista School of Medicine, São Paulo Hospital, Federal University of São Paulo, Brazil, Institute of Psychology, University of São Paulo, São Paulo, Brazil
dc.affiliationParanhos, A., Department of Ophthalmology and Visual Sciences, Paulista School of Medicine, São Paulo Hospital, Federal University of São Paulo, Brazil, Hospital Israelita Albert Einstein, São Paulo, Brazil
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