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Characterization of airborne particulate matter and its toxic and proarrhythmic effects: A case study in Aburrá Valley, Colombia

dc.contributor.authorPalacio L.C
dc.contributor.authorDurango-Giraldo G
dc.contributor.authorZapata-Hernandez C
dc.contributor.authorSanta-González G.A
dc.contributor.authorUribe D
dc.contributor.authorSaiz J
dc.contributor.authorBuitrago-Sierra R
dc.contributor.authorTobón C.
dc.date.accessioned2024-07-31T21:07:12Z
dc.date.available2024-07-31T21:07:12Z
dc.date.created2023
dc.identifier.issn2697491
dc.identifier.urihttp://hdl.handle.net/11407/8502
dc.descriptionParticle matter (PM) is a complex mixture of particles suspended in the air, mainly caused by fuel combustion from vehicles and industry, and has been related to pulmonary and cardiovascular diseases. The Metropolitan Area of Aburrá Valley in Colombia is the second most populous urban agglomeration in the country and the third densest in the world, composed of ten municipalities. Examining the physicochemical properties of PM is crucial in comprehending its composition and its effects on human health, as it varies based on the socioeconomic dynamics specific to each city. This study characterized the PM collected from the north, south, and central zones to evaluate its chemical composition and morphology. Different elements such as silicon, carbon, aluminum, potassium, calcium, sodium, iron, magnesium, and copper and the presence of unburned fuel, motor oil, and silicon fibers were identified. In vitro and in silico studies were conducted to evaluate the toxicity of the PM, and it was found that the PM collected from the central zone had the greatest impact on cell viability and caused DNA damage. The in silico study demonstrated that PM has concentration-dependent proarrhythmic effects, reflected in an action potential duration shortening and an increased number of reentries, which may contribute to the development of cardiac arrhythmias. Overall, the results suggest that the size and chemical composition of ambient PM can induce toxicity and play an important role in the generation of arrhythmias. © 2023 The Authors
dc.language.isoeng
dc.publisherElsevier Ltd
dc.relation.isversionofhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85170206623&doi=10.1016%2fj.envpol.2023.122475&partnerID=40&md5=a2433de5319cefb551cc3f455cd587c3
dc.sourceEnvironmental Pollution
dc.sourceEnviron. Pollut.
dc.sourceScopus
dc.subjectCytotoxicityeng
dc.subjectGenotoxicityeng
dc.subjectHeart diseaseseng
dc.subjectIn vitro and in silico modelseng
dc.subjectParticulate mattereng
dc.titleCharacterization of airborne particulate matter and its toxic and proarrhythmic effects: A case study in Aburrá Valley, Colombiaeng
dc.typearticle
dc.rights.accessrightsinfo:eu-repo/semantics/restrictedAccess
dc.type.spaArtículo
dc.identifier.doi10.1016/j.envpol.2023.122475
dc.relation.citationvolume336
dc.publisher.facultyFacultad de Ciencias Básicasspa
dc.affiliationPalacio, L.C., MATBIOM, Facultad de Ciencias Básicas, Universidad de Medellín, Medellín, Colombia
dc.affiliationDurango-Giraldo, G., MATyER, Facultad de Ingeniería, Institución Universitaria ITM, Medellín, Colombia, Departament of Textile and Paper engineering, Polytechnical University of Catalonia, Barcelona, Spain
dc.affiliationZapata-Hernandez, C., MATBIOM, Facultad de Ciencias Básicas, Universidad de Medellín, Medellín, Colombia, MATyER, Facultad de Ingeniería, Institución Universitaria ITM, Medellín, Colombia
dc.affiliationSanta-González, G.A., GI2B, Facultad de Ciencias Exactas y Aplicadas, Institución Universitaria ITM, Medellín, Colombia
dc.affiliationUribe, D., GI2B, Facultad de Ciencias Exactas y Aplicadas, Institución Universitaria ITM, Medellín, Colombia
dc.affiliationSaiz, J., CI2B, Universitat Politècnica de València, Valencia, Spain
dc.affiliationBuitrago-Sierra, R., MATyER, Facultad de Ingeniería, Institución Universitaria ITM, Medellín, Colombia
dc.affiliationTobón, C., MATBIOM, Facultad de Ciencias Básicas, Universidad de Medellín, Medellín, Colombia
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dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.reponamereponame:Repositorio Institucional Universidad de Medellín
dc.identifier.repourlrepourl:https://repository.udem.edu.co/
dc.identifier.instnameinstname:Universidad de Medellín


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