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Design and Construction of a Synthetic Nanobody Library: Testing Its Potential with a Single Selection Round Strategy
Nanobodies (Nbs) are single domain antibody fragments derived from heavy-chain antibodies found in members of the Camelidae family. They have become a relevant class of biomolecules for many different applications because ...
Engineered synthetic nanobody-based biosensors for electrochemical detection of epidermal growth factor receptor
Two engineered synthetic nanobody-based nanobiocomposite platforms were developed for label-free electrochemical detection of the epithelial growth factor receptor (EGFR) biomarker. Screen-printed carbon electrodes (SPCE) ...
Selecting Nanobodies Specific for the Epidermal Growth Factor from a Synthetic Nanobody Library
The epidermal growth factor (EGF) is one of the most critical ligands of the EGF receptor (EGFR), a well-known oncogene frequently overexpressed in cancerous cells and an important therapeutic target in cancer. The EGF is ...
Structural Modeling of Nanobodies: A Benchmark of State-of-the-Art Artificial Intelligence Programs
The number of applications for nanobodies is steadily expanding, positioning these molecules as fast-growing biologic products in the biotechnology market. Several of their applications require protein engineering, which ...