Lead (Pb++) effect on human atrial action potential under normal and atrial fibrillation conditions. In silico study
MATBIOM, Universidad de Medellín, Medellín, Colombia
GI2B, Instituto Tecnológico Metropolitano, Medellín, Colombia
Grupo de Dinámica Cardiovascular, Universidad Pontificia Bolivariana, Medellín, Colombia
CI2B, Universitat Politècnica de València, Valencia, Spain
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Lead (Pb++) is a toxic agent that can exert adverse effects on the cardiac human health. Pb++ blocks the Ltype Ca++ channels. A decrease in L-type calcium current (ICaL) is an important mechanism favoring atrial fibrillation. It is important to study the electrophysiological Pb++ effects on the atrial action potential in healthy people and those with AF. For this, we study the consequences of Pb++ on action potential, under normal and atrial fibrillation condition using in silico models. Our results suggest that Pb++ blocks ICaL current in a fraction greater as the concentration increases, resulting in an action potential duration shortening, Pb++ has a greater action potential duration effect on control conditions. To our knowledge, this is the first work that has developed mathematical models of Pb++ effect on ICaLcurrent to study its effect on human atrial action potential. © Springer Nature Singapore Pte Ltd. 2017.
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