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Dofetilide effect on human atrial action potential under normal and atrial fibrillation conditions. In silico study

dc.creatorTobón C.spa
dc.creatorPérez S.spa
dc.creatorUgarte J.P.spa
dc.creatorSaiz J.spa
dc.date.accessioned2017-12-19T19:36:43Z
dc.date.available2017-12-19T19:36:43Z
dc.date.created2017
dc.identifier.isbn9789811040856
dc.identifier.issn16800737
dc.identifier.urihttp://hdl.handle.net/11407/4275
dc.description.abstractAtrial fibrillation is the most common sustained cardiac arrhythmia. Dofetilide is an antiarrhythmic drug for the treatment of chronic AF that specifically blocks the rapid component of the delayed rectifier potassium current IKr. Dofetilide prolongs the action potential duration and QT interval in a concentration-dependent fashion, therefore, the risk of QT prolongation is dose related. It is important to study the electrophysiological effects of dofetilide at different concentrations in human atrial cells. For this, we simulated the effects of dofetilide on human atrial cell and studied its effect on atrial action potential under normal conditions and during cAF. We developed a model of dofetilide effects on IKrand IKACh. Our results show that dofetilide blocks both currents in a fraction greater as the concentration increases, which results in an action potential duration lengthening. To our knowledge, this is the first work that has developed mathematical models of dofetilide effects on IKrand IKAChcurrents to study its effect on human atrial action potential. © Springer Nature Singapore Pte Ltd. 2017.eng
dc.language.isoeng
dc.publisherSpringer Verlagspa
dc.relation.isversionofhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85018409745&doi=10.1007%2f978-981-10-4086-3_10&partnerID=40&md5=280d9472ab3c08a89e7be6b0469e002espa
dc.sourceScopusspa
dc.titleDofetilide effect on human atrial action potential under normal and atrial fibrillation conditions. In silico studyspa
dc.typeConference Papereng
dc.rights.accessrightsinfo:eu-repo/semantics/restrictedAccess
dc.contributor.affiliationTobón, C., MATBIOM, Universidad de Medellín, Medellín, Colombiaspa
dc.contributor.affiliationPérez, S., Grupo de Dinámica Cardiovascular, Universidad Pontificia Bolivariana, Medellín, Colombiaspa
dc.contributor.affiliationUgarte, J.P., Grupo de Dinámica Cardiovascular, Universidad Pontificia Bolivariana, Medellín, Colombiaspa
dc.contributor.affiliationSaiz, J., CI2B, Universitat Politècnica de València, Valencia, Spainspa
dc.identifier.doi10.1007/978-981-10-4086-3_10
dc.subject.keywordAntiarrhythmic drugeng
dc.subject.keywordAtrial fibrillationeng
dc.subject.keywordDofetilideeng
dc.subject.keywordIn silico modeleng
dc.subject.keywordBiomedical engineeringeng
dc.subject.keywordElectric rectifierseng
dc.subject.keywordElectrophysiologyeng
dc.subject.keywordAction potential durationseng
dc.subject.keywordAntiarrhythmic drugeng
dc.subject.keywordAtrial fibrillationeng
dc.subject.keywordCardiac arrhythmiaeng
dc.subject.keywordConcentration-dependenteng
dc.subject.keywordDofetilideeng
dc.subject.keywordIn-silico modelseng
dc.subject.keywordPotassium currentseng
dc.subject.keywordDiseaseseng
dc.publisher.facultyFacultad de Ciencias Básicasspa
dc.abstractAtrial fibrillation is the most common sustained cardiac arrhythmia. Dofetilide is an antiarrhythmic drug for the treatment of chronic AF that specifically blocks the rapid component of the delayed rectifier potassium current IKr. Dofetilide prolongs the action potential duration and QT interval in a concentration-dependent fashion, therefore, the risk of QT prolongation is dose related. It is important to study the electrophysiological effects of dofetilide at different concentrations in human atrial cells. For this, we simulated the effects of dofetilide on human atrial cell and studied its effect on atrial action potential under normal conditions and during cAF. We developed a model of dofetilide effects on IKrand IKACh. Our results show that dofetilide blocks both currents in a fraction greater as the concentration increases, which results in an action potential duration lengthening. To our knowledge, this is the first work that has developed mathematical models of dofetilide effects on IKrand IKAChcurrents to study its effect on human atrial action potential. © Springer Nature Singapore Pte Ltd. 2017.eng
dc.creator.affiliationMATBIOM, Universidad de Medellín, Medellín, Colombiaspa
dc.creator.affiliationGrupo de Dinámica Cardiovascular, Universidad Pontificia Bolivariana, Medellín, Colombiaspa
dc.creator.affiliationCI2B, Universitat Politècnica de València, Valencia, Spainspa
dc.relation.ispartofesIFMBE Proceedingsspa
dc.relation.ispartofesIFMBE Proceedings Volume 60, 2017, Pages 38-41spa
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dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.type.driverinfo:eu-repo/semantics/conferenceObject
dc.identifier.reponamereponame:Repositorio Institucional Universidad de Medellínspa
dc.identifier.instnameinstname:Universidad de Medellínspa


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