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Lead and carbon monoxide effects on human atrial action potential. In silico study

dc.creatorTobón C.spa
dc.creatorPachajoa D.C.spa
dc.creatorUgarte J.P.spa
dc.creatorOrozco-Duque A.spa
dc.creatorSaiz J.spa
dc.date.accessioned2018-10-31T13:44:24Z
dc.date.available2018-10-31T13:44:24Z
dc.date.created2017
dc.identifier.issn23258861
dc.identifier.urihttp://hdl.handle.net/11407/4914
dc.descriptionExposure to air pollutants like lead (Pb++) and carbon monoxide (CO), promotes the occurrence of cardiovascular diseases. Experimental studies have shown that Pb++ and CO block the L-type calcium channels, decreasing the calcium current (ICaL) and the action potential duration (APD), favoring the initiation of atrial arrhythmias. Our goal is to study the effects of Pb++ and CO at different concentrations, on ICaL and action potential using computational simulation. For this, we developed mathematical models of the air pollutants effects on the atrial L-type calcium channel and they were incorporated in a mathematical model of human atrial cell and in a 2D model of atrial tissue. Our results suggest that the Pb++ and CO block the ICaL current in a fraction that increases as the concentration increases, generating an APD shortening. The combined effect of both air pollutants generated an APD shortening and a stable rotor, which is considered as a pro-arrhythmic effect. These results are consistent with experimental studies. In silico studies may contribute to a better understanding of the mechanisms by which air pollutants have unhealthy effects on cardiac system. © 2017 IEEE Computer Society. All rights reserved.spa
dc.language.isoeng
dc.publisherIEEE Computer Societyspa
dc.relation.isversionofhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85045124430&doi=10.22489%2fCinC.2017.123-037&partnerID=40&md5=fe262767368ee1e80a222bc4e723bae5spa
dc.sourceScopusspa
dc.subjectAir pollutionspa
dc.subjectCalciumspa
dc.subjectCalcium compoundsspa
dc.subjectCarbon monoxidespa
dc.subjectCardiologyspa
dc.subjectAction potential durationsspa
dc.subjectAction potentialsspa
dc.subjectAtrial arrhythmiaspa
dc.subjectCalcium currentspa
dc.subjectCardio-vascular diseasespa
dc.subjectCombined effectspa
dc.subjectComputational simulationspa
dc.subjectL-type calcium channelsspa
dc.subjectLead compoundsspa
dc.titleLead and carbon monoxide effects on human atrial action potential. In silico studyspa
dc.typeConference Papereng
dc.rights.accessrightsinfo:eu-repo/semantics/restrictedAccess
dc.publisher.programCiencias Básicasspa
dc.contributor.affiliationTobón, C., Universidad de Medellín;Pachajoa, D.C., Instituto Tecnológico Metropolitano;Ugarte, J.P., Universidad de San Buenaventura;Orozco-Duque, A., Instituto Tecnológico Metropolitano;Saiz, J., Universitat Politècnica de Valènciaspa
dc.identifier.doi10.22489/CinC.2017.123-037
dc.relation.citationvolume44
dc.relation.citationstartpage1
dc.relation.citationendpage4
dc.publisher.facultyFacultad de Ciencias Básicasspa
dc.relation.ispartofesComputing in Cardiologyspa
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dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.type.driverinfo:eu-repo/semantics/conferenceObject


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