Mostrar el registro sencillo del ítem

dc.creatorPerez-Buitrago S.
dc.creatorUgarte J.P.
dc.creatorTobon C.
dc.date2018
dc.date.accessioned2020-04-29T14:53:46Z
dc.date.available2020-04-29T14:53:46Z
dc.identifier.isbn9781728109589
dc.identifier.issn23258861
dc.identifier.urihttp://hdl.handle.net/11407/5719
dc.descriptionThe rotor ablation has gained favor in recent years to treat chronic atrial fibrillation (CAF). However, it may cause complications in patients and the results remain suboptimal. Besides, antiarrhythmic drugs for the management of AF are not sufficiently effective and can cause significant cardiac and extracardiac side effects. To reduce the risk and increase the effectiveness, a rotor modulation via the localized release of dofetilide is proposed through an in silico study. A computational model of two-dimensional atrial tissue was implemented using human cell model under CAF conditions. Dofetilide was modeled blocking the ionic currents IKr and IKACH using Hill's equation. A CAF episode, sustained by a rotor, was simulated. Different concentrations of dofetilide were applied in specific distributions based on the rotor tip location, detected by phase map analysis. Non-localized application of dofetilide resulted in the benefit of CAF progression. In contrast, localized dofetilide liberation terminated the CAF episode. These results could have therapeutic implications in novel treatments of CAF. © 2018 Creative Commons Attribution.
dc.language.isoeng
dc.publisherIEEE Computer Society
dc.relation.isversionofhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85068790406&doi=10.22489%2fCinC.2018.359&partnerID=40&md5=3dcc390ee631638e8d87e8e20a2b1592
dc.sourceComputing in Cardiology
dc.subjectCardiology
dc.subjectDrug interactions
dc.subjectModulation
dc.subjectAntiarrhythmic drug
dc.subjectAtrial fibrillation
dc.subjectAtrial tissues
dc.subjectComputational model
dc.subjectHill's equation
dc.subjectNon-localized
dc.subjectRotor modulation
dc.subjectSpecific distribution
dc.subjectRoom and pillar mining
dc.titleAtrial Rotor Modulation by Localized Dofetilide Application: An in Silico Study
dc.typeConference Papereng
dc.rights.accessrightsinfo:eu-repo/semantics/restrictedAccess
dc.publisher.programFacultad de Ciencias Básicas
dc.identifier.doi10.22489/CinC.2018.359
dc.relation.citationvolume2018-September
dc.publisher.facultyFacultad de Ciencias Básicas
dc.affiliationPerez-Buitrago, S., GI2B, Instituto Tecnológico Metropolitano, Calle 73 No. 76A - 354, Medellìn, 050034, Colombia; Ugarte, J.P., GIMSC, Universidad de San Buenaventura, Medellín, Colombia; Tobon, C., MATBIOM, Universidad de Medellín, Medellín, Colombia
dc.relation.referencesLau, D.H., Linz, D., Schotten, U., Mahajan, R., Sanders, P., Kalman, J.M., Pathophysiology of paroxysmal and persistent atrial fibrillation: Rotors, foci and fibrosis (2017) Hear. Lung Circ, 9506 (17), pp. 1-7
dc.relation.referencesKrummen, D.E., Swarup, V., Narayan, S.M., The role of rotors in atrial fibrillation (2015) J. Thorac. Dis, 7 (2), pp. 142-151. , Feb
dc.relation.referencesParameswaran, R., Voskoboinik, A., Gorelik, A., Lee, G., Kistler, P.M., Sanders, P., Kalman, J.M., Clinical impact of rotor ablation in atrial fibrillation: A systematic review (2018) EP Eur, 20 (7), pp. 1099-1106. , Jul
dc.relation.referencesRavens, U., Odening, K.E., Atrial fibrillation: Therapeutic potential of atrial K+ channel blockers (2017) Pharmacol. Ther, 176, pp. 13-21. , Aug
dc.relation.referencesTobón, C., Pérez, S., Ugarte, J.P., Saiz, J., Dofetilide effect on human atrial action potential under normal and atrial fibrillation conditions (2016) Silico Study BT-VII Latin American Congress on Biomedical Engineering CLAIB 2016, 2017, pp. 38-41. , Bucaramanga, Santander, Colombia, October 26th-28th
dc.relation.referencesCourtemanche, M., Ramirez, R.J., Nattel, S., Ionic mechanisms underlying human atrial action potential properties: Insights from a mathematical model (1998) Am. J. Physiol, 275 (1), pp. H301-H321. , Jul
dc.relation.referencesCourtemanche, M., Ramirez, R.J., Nattel, S., Ionic targets for drug therapy and atrial fibrillation-induced electrical remodeling: Insights from a mathematical model (1999) Cardiovasc. Res, 42 (2), pp. 477-489. , May
dc.relation.referencesVan Wagoner, D.R., Electrophysiological remodeling in human atrial fibrillation (2003) Pacing Clin. Electrophysiol, 26 (7), pp. 1572-1575
dc.relation.referencesFicker, E., Jarolimek, W., Kiehn, J., Baumann, A., Brown, A.M., (2015) Molecular Determinants of Dofetilide Block of HERG K Channels, pp. 386-395
dc.relation.referencesVoigt, N., Rozmaritsa, N., Trausch, A., Zimniak, T., Christ, T., Wettwer, E., Matschke, K., Ravens, U., Inhibition of IK,ACh current may contribute to clinical efficacy of class i and class III antiarrhythmic drugs in patients with atrial fibrillation (2010) Naunyn. Schmiedebergs. Arch. Pharmacol, 381 (3), pp. 251-259
dc.relation.referencesBueno-Orovio, A., Kay, D., Burrage, K., Fourier spectral methods for fractional-in-space reaction-diffusion equations (2014) BIT Numer. Math, 54 (4), pp. 937-954
dc.relation.referencesBerenfeld, O., The major role of IK1 in mechanisms of rotor drift in the atria : A computational study (2016) Clin. Med. Insights Cardiol, 10, pp. 71-79
dc.relation.referencesUgarte, J.P., Tobón, C., Orozco-Duque, A., Becerra, M.A., Bustamante, J., Effect of the electrograms density in detecting and ablating the tip of the rotor during chronic atrial fibrillation: An in silico study (2015) Europace, 17, pp. ii97-ii104
dc.relation.referencesGuillem, M., Climent, A.M., Rodrigo, M., Fernandez-Aviles, F., Atienza, F., Berenfeld, O., Presence and stability of rotors in atrial fibrillation: Evidence and therapeutic implications (2016) Cardiovasc. Res, 109 (4), pp. 480-492
dc.relation.referencesSingh, S., Zoble, R.G., Yellen, L., Brodsky, M.A., Feld, G.K., Berk, M., Billing, C.B., Efficacy and safety of oral dofetilide in converting to and maintaining sinus rhythm in patients with chronic atrial fibrillation or atrial flutter: The symptomatic atrial fibrillation investigative research on dofetilide (SAFIRE-D) study (2000) Circulation, 102 (19), pp. 2385-2390
dc.relation.referencesAllen, M.J., Nichols, D.J., Oliver, S.D., The pharmacokinetics and pharmacodynamics of oral dofetilide after twice daily and three times daily dosing (2000) Clin. Pharmacol, 50, pp. 247-253
dc.relation.referencesJaiswal, A., Goldbarg, S., Dofetilide induced torsade de pointes: Mechanism, risk factors and management strategies (2014) Indian Heart J, 66 (6), pp. 640-648
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.type.driverinfo:eu-repo/semantics/article


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem