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Genesis of Atrial Fibrillation Under Different Diffuse Fibrosis Density Related with Atmospheric Pollution. In-Silico Study

dc.creatorPalacio L.C.
dc.creatorUgarte J.P.
dc.creatorSaiz J.
dc.creatorTobón C.
dc.date2020
dc.date.accessioned2021-02-05T14:58:18Z
dc.date.available2021-02-05T14:58:18Z
dc.identifier.isbn9783030618339
dc.identifier.issn18650929
dc.identifier.urihttp://hdl.handle.net/11407/5963
dc.descriptionAtrial remodeling is a widely acknowledged process that accelerates the susceptibility to and progression of atrial fibrillation. An increasingly recognized structural component is atrial fibrosis. Recent studies have shown that air pollution increases the risk of heart arrhythmias, where the exposure to particulate matter (PM) contributes to the generation of myocardial fibrosis, increasing the cardiovascular risk. The density and patterns of fibrosis (interstitial, compact and diffuse) are relevant in abnormal conduction and vulnerability to cardiac arrhythmias. Taking into account that fibrosis has been widely reported as one of the consequences of PM exposure, in this work, we evaluated the effects of low and high diffuse fibrosis density on conduction velocity and arrhythmic propagation patterns. For this purpose, cellular models of atrial myocyte and fibroblast were implemented in a 3D model of the human atria. Low (6.25%) and high (25%) fibrosis densities were simulated in the left atrium and its effect on conduction velocity and fibrillatory dynamics was evaluated. Results showed a conduction velocity reduction of 71% associated with a high fibrosis density. At low fibrosis density, few reentries were observed. On the other hand, at high fibrosis density, irregular propagation patterns, characterized by multiple wavelets and rotors, were observed. Our results suggest that high diffuse fibrosis density is associated with a significant conduction velocity reduction and with chaotic propagation patterns during atrial fibrillation. © 2020, Springer Nature Switzerland AG.
dc.language.isoeng
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.relation.isversionofhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85094125733&doi=10.1007%2f978-3-030-61834-6_25&partnerID=40&md5=e03a170ed38f94b299efb68c1a0ccd22
dc.sourceCommunications in Computer and Information Science
dc.subject3D modelsspa
dc.subjectAir pollutionspa
dc.subjectAtrial fibrillationspa
dc.subjectFibrosisspa
dc.titleGenesis of Atrial Fibrillation Under Different Diffuse Fibrosis Density Related with Atmospheric Pollution. In-Silico Study
dc.typeConference Papereng
dc.rights.accessrightsinfo:eu-repo/semantics/restrictedAccess
dc.identifier.doi10.1007/978-3-030-61834-6_25
dc.subject.keyword3D modelingeng
dc.subject.keywordAir pollutioneng
dc.subject.keywordCell cultureeng
dc.subject.keywordVelocityeng
dc.subject.keywordAtmospheric pollutioneng
dc.subject.keywordAtrial fibrillationeng
dc.subject.keywordCardiovascular riskeng
dc.subject.keywordConduction velocityeng
dc.subject.keywordMyocardial fibrosiseng
dc.subject.keywordParticulate Mattereng
dc.subject.keywordPropagation patterneng
dc.subject.keywordStructural componenteng
dc.subject.keywordDiseaseseng
dc.relation.citationvolume1274 CCIS
dc.relation.citationstartpage291
dc.relation.citationendpage301
dc.publisher.facultyFacultad de Ciencias Básicasspa
dc.affiliationPalacio, L.C., MATBIOM, Universidad de Medellín, Medellín, Colombia
dc.affiliationUgarte, J.P., GIMSC, Universidad de San Buenaventura, Medellín, Colombia
dc.affiliationSaiz, J., CI2B, Universitat Politècnica de València, Valencia, Spain
dc.affiliationTobón, C., MATBIOM, Universidad de Medellín, Medellín, Colombia
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