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Fibrillatory conduction in a simulated two-dimensional model of human atrial tissue: effect of the interaction of two ectopic foci

dc.creatorTobón C.
dc.creatorSaiz J.
dc.date2019
dc.date.accessioned2021-02-05T14:59:10Z
dc.date.available2021-02-05T14:59:10Z
dc.identifier.issn375497
dc.identifier.urihttp://hdl.handle.net/11407/6076
dc.descriptionAtrial fibrillation (AF) is the most common tachyarrhythmia. It has been demonstrated that extra-stimuli could act as triggers for AF. In many patients it is possible that multiple ectopic foci co-exist, and their interactions may generate complex conduction patterns. Our goal is to investigate the influence of the focus frequency, conduction velocity, and anisotropy on fibrillatory pattern generation during the interaction of multiple ectopic activities under electrical remodeling conditions. Our results support the broadly accepted theory that ectopic activity acting in remodeled tissue is an initiator of reentrant mechanisms. These reentrant circuits can generate fibrillatory activity when interacting with other rapid ectopic foci and under the following conditions: high ectopic focus frequency, slow conduction velocity, and anisotropic tissue. Analyses of electrogram polymorphism allow determination of which zones of tissue permit one to know in which zone of tissue unstable activity exists. Our results give useful insights into the electrophysiological parameters that determine the initiation and maintenance of fibrillatory conduction by two ectopic foci interaction in a simulated two-dimensional sheet of human atrial cells, under chronic AF conditions. © The Author(s) 2018.
dc.language.isoeng
dc.publisherSAGE Publications Ltd
dc.relation.isversionofhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85049863457&doi=10.1177%2f0037549718782401&partnerID=40&md5=9f33b0ab12b0fd3f7d6c0929d31d6a05
dc.sourceSimulation
dc.subjectectopic activityspa
dc.subjectfibrillatory conductionspa
dc.subjectTwo-dimensional atrial modelspa
dc.titleFibrillatory conduction in a simulated two-dimensional model of human atrial tissue: effect of the interaction of two ectopic foci
dc.typeArticleeng
dc.rights.accessrightsinfo:eu-repo/semantics/restrictedAccess
dc.identifier.doi10.1177/0037549718782401
dc.subject.keywordAnisotropyeng
dc.subject.keywordElectrophysiologyeng
dc.subject.keywordTissueeng
dc.subject.keywordAtrial fibrillationeng
dc.subject.keywordAtrial modelseng
dc.subject.keywordConduction patternseng
dc.subject.keywordConduction velocityeng
dc.subject.keywordElectrical remodelingeng
dc.subject.keywordFibrillatory conductioneng
dc.subject.keywordPattern Generationeng
dc.subject.keywordTwo dimensional modeleng
dc.subject.keywordTissue engineeringeng
dc.relation.citationvolume95
dc.relation.citationissue7
dc.relation.citationstartpage577
dc.relation.citationendpage591
dc.publisher.facultyFacultad de Ciencias Básicasspa
dc.affiliationTobón, C., MATBIOM, Universidad de Medellín, Colombia
dc.affiliationSaiz, J., CI2B, Universitat Politècnica de Valencia, Spain
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