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A computational view of electrophysiological properties under different atrial fibrosis conditions

dc.contributor.authorUgarte J.P
dc.contributor.authorTobón C
dc.contributor.authorTenreiro Machado J.A.
dc.date.accessioned2022-09-14T14:33:26Z
dc.date.available2022-09-14T14:33:26Z
dc.date.created2022
dc.identifier.issn0307904X
dc.identifier.urihttp://hdl.handle.net/11407/7362
dc.descriptionThe excessive proliferation of fibroblasts causes fibrosis, a hallmark of atrial fibrillation (AF), and leads to alterations in the electrical conduction within the heart. However, the underlying electrophysiological mechanisms behind the multifactorial characteristic of AF fibrosis are not fully understood. This work studies the electrophysiological properties of different fibrosis configurations using computational simulations. For this purpose, the intermingling action of the structural and electrical remodeling due to fibroblasts are implemented in an electrophysiological description of the AF fibrosis. The model is built on the base of complex order operators and a fibroblast ionic formulation. Additionally, three fibrosis textures are considered for designing the atrial tissue representations. The resting and depolarization properties are analyzed by means of information theory and multidimensional scaling. The results evinced that the modulation of cardiomyocytes resting potential, exerted by the fibroblasts, is the mechanism giving rise to emergent electrophysiological properties as a result of the synergetic mathematical formulation of the proposed fibrosis model. The metrics assessing such properties unravel distinctive signatures of each fibrosis texture. Additionally, the multidimensional scaling computational tool reveals clusters specifically determined by the resting and depolarization properties, or by their combination. The observed clusters support an electrophysiological interpretation through the underlying fibrosis configuration, in which the diffuse, patchy and compact textures are relevant in determining the emergent patterns. © 2022 Elsevier Inc.eng
dc.language.isoeng
dc.publisherElsevier Inc.
dc.relation.isversionofhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85123362497&doi=10.1016%2fj.apm.2021.12.049&partnerID=40&md5=a42a696104b375cc97751fb61f051633
dc.sourceApplied Mathematical Modelling
dc.titleA computational view of electrophysiological properties under different atrial fibrosis conditions
dc.typeArticle
dc.rights.accessrightsinfo:eu-repo/semantics/restrictedAccess
dc.publisher.programCiencias Básicas
dc.type.spaArtículo
dc.identifier.doi10.1016/j.apm.2021.12.049
dc.subject.keywordCardiac computationeng
dc.subject.keywordClusteringeng
dc.subject.keywordComplex order operatorseng
dc.subject.keywordFibroblastseng
dc.subject.keywordFractional calculuseng
dc.subject.keywordMultidimensional scalingeng
dc.subject.keywordCell cultureeng
dc.subject.keywordComputation theoryeng
dc.subject.keywordDepolarizationeng
dc.subject.keywordElectrophysiologyeng
dc.subject.keywordFibroblastseng
dc.subject.keywordInformation theoryeng
dc.subject.keywordTextureseng
dc.subject.keywordAtrial fibrillationeng
dc.subject.keywordCardiac computationeng
dc.subject.keywordClusteringseng
dc.subject.keywordComplex order operatoreng
dc.subject.keywordConditioneng
dc.subject.keywordElectrical conductioneng
dc.subject.keywordElectrophysiological propertieseng
dc.subject.keywordFractional calculuseng
dc.subject.keywordMulti-dimensional scalingeng
dc.subject.keywordPropertyeng
dc.subject.keywordCalculationseng
dc.relation.citationvolume105
dc.relation.citationstartpage534
dc.relation.citationendpage550
dc.publisher.facultyFacultad de Ciencias Básicas
dc.affiliationUgarte, J.P., GIMSC, Universidad de San Buenaventura, Medellín, Colombia
dc.affiliationTobón, C., MATBIOM, Universidad de Medellín, Medellín, Colombia
dc.affiliationTenreiro Machado, J.A., Department of Electrical Engineering, Institute of Engineering, Polytechnic of Porto, Porto, Portugal
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dc.type.coarhttp://purl.org/coar/resource_type/c_6501
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.type.driverinfo:eu-repo/semantics/article
dc.identifier.reponamereponame:Repositorio Institucional Universidad de Medellín
dc.identifier.repourlrepourl:https://repository.udem.edu.co/
dc.identifier.instnameinstname:Universidad de Medellín


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