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Carbon Monoxide Effect on Human Cardiac Tissue. In Silico Study

dc.contributor.authorTobón C
dc.contributor.authorDurango-Giraldo G
dc.contributor.authorUgarte J.P.
dc.date.accessioned2022-09-14T14:33:30Z
dc.date.available2022-09-14T14:33:30Z
dc.date.created2021
dc.identifier.isbn9783030867010
dc.identifier.issn18650929
dc.identifier.urihttp://hdl.handle.net/11407/7403
dc.descriptionThe Exposure to atmospheric pollutants, such as carbon monoxide (CO), promotes the appearance of cardiovascular diseases. Studies have shown that CO blocks calcium channels, leading to a decrease of the ICaL current and to a shortening of the action potential duration (APD); favoring the generation of cardiac arrhythmias. The aim of this work is to study the CO effects, at different concentrations, on the atrial and ventricular tissues using computational simulations. An equation of the CO effect on ICaL was developed. It was included in two mathematical models of human atrial and ventricular cells, under normal physiological conditions. Atrial and ventricular 2D models were developed to evaluate the CO effect on the generation of reentries as an arrhythmogenic mechanism. The results show that CO blocks the ICaL current in a greater fraction as its concentration increases, causing APD shortening. Such effect is larger in atrial cardiomycytes. Arrhythmic events (rotors) were generated at the high CO concentration in atrial tissue. In ventricular tissue it was not possible to generate rotors. This study provides a first step in investigating the proarrhythmic effects of CO in healthy people. © 2021, Springer Nature Switzerland AG.eng
dc.language.isoeng
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.relation.isversionofhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85116812079&doi=10.1007%2f978-3-030-86702-7_14&partnerID=40&md5=38a5b8340518ffe70cb68d860db3b016
dc.sourceCommunications in Computer and Information Science
dc.titleCarbon Monoxide Effect on Human Cardiac Tissue. In Silico Study
dc.typeConference Paper
dc.rights.accessrightsinfo:eu-repo/semantics/restrictedAccess
dc.publisher.programCiencias Básicas
dc.type.spaDocumento de conferencia
dc.identifier.doi10.1007/978-3-030-86702-7_14
dc.subject.keywordAction potentialeng
dc.subject.keywordCarbon monoxideeng
dc.subject.keywordIn silico modelseng
dc.subject.keywordL-type calcium currenteng
dc.subject.keywordReentrieseng
dc.subject.keywordCalciumeng
dc.subject.keywordDiseaseseng
dc.subject.keywordPhysiological modelseng
dc.subject.keywordTissueeng
dc.subject.keyword'currenteng
dc.subject.keywordAction potential durationseng
dc.subject.keywordAction-potentialseng
dc.subject.keywordAtmospheric pollutantseng
dc.subject.keywordCalcium currenteng
dc.subject.keywordCardiac tissueseng
dc.subject.keywordIn-silicoeng
dc.subject.keywordIn-silico modelseng
dc.subject.keywordL-type calcium currenteng
dc.subject.keywordSilico studieseng
dc.subject.keywordCarbon monoxideeng
dc.relation.citationvolume1431 CCIS
dc.relation.citationstartpage160
dc.relation.citationendpage170
dc.publisher.facultyFacultad de Ciencias Básicas
dc.affiliationTobón, C., MATBIOM, Universidad de Medellín, Medellín, Colombia
dc.affiliationDurango-Giraldo, G., MATBIOM, Universidad de Medellín, Medellín, Colombia
dc.affiliationUgarte, J.P., GIMSC, Universidad de San Buenaventura, Medellín, Colombia
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dc.type.coarhttp://purl.org/coar/resource_type/c_5794
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.type.driverinfo:eu-repo/semantics/other
dc.identifier.reponamereponame:Repositorio Institucional Universidad de Medellín
dc.identifier.repourlrepourl:https://repository.udem.edu.co/
dc.identifier.instnameinstname:Universidad de Medellín
dc.relation.ispartofconference8th Workshop on Engineering Applications, WEA 2021


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