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Genetic modification approaches for parasporins bacillus thuringiensis proteins with anticancer activity

dc.contributor.authorSuárez-Barrera M.O
dc.contributor.authorVisser L
dc.contributor.authorRondón-Villarreal P
dc.contributor.authorHerrera-Pineda D.F
dc.contributor.authorAlarcón-Aldana J.S
dc.contributor.authorVan den Berg A
dc.contributor.authorOrozco J
dc.contributor.authorPinzón-Reyes E.H
dc.contributor.authorMoreno E
dc.contributor.authorRueda-Forero N.J.
dc.date.accessioned2022-09-14T14:33:47Z
dc.date.available2022-09-14T14:33:47Z
dc.date.created2021
dc.identifier.issn14203049
dc.identifier.urihttp://hdl.handle.net/11407/7471
dc.descriptionBacillus thuringiensis (Bt) is a bacterium capable of producing Cry toxins, which are recognized for their bio-controlling actions against insects. However, a few Bt strains encode proteins lacking insecticidal activity but showing cytotoxic activity against different cancer cell lines and low or no cytotoxicity toward normal human cells. A subset of Cry anticancer proteins, termed parasporins (PSs), has recently arisen as a potential alternative for cancer treatment. However, the molecular receptors that allow the binding of PSs to cells and their cytotoxic mechanisms of action have not been well established. Nonetheless, their selective cytotoxic activity against different types of cancer cell lines places PSs as a promising alternative treatment modality. In this review, we provide an overview of the classification, structures, mechanisms of action, and insights obtained from genetic modification approaches for PS proteins. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.eng
dc.language.isoeng
dc.publisherMDPI
dc.relation.isversionofhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85121542572&doi=10.3390%2fmolecules26247476&partnerID=40&md5=d0ac1512241065ca55dd2d8f6b3ccdad
dc.sourceMolecules
dc.titleGenetic modification approaches for parasporins bacillus thuringiensis proteins with anticancer activity
dc.typeReview
dc.rights.accessrightsinfo:eu-repo/semantics/restrictedAccess
dc.publisher.programCiencias Básicas
dc.type.spaRevisión
dc.identifier.doi10.3390/molecules26247476
dc.subject.keywordCancer cellseng
dc.subject.keywordCry toxinseng
dc.subject.keywordGenetic improvementeng
dc.subject.keywordParasporinseng
dc.relation.citationvolume26
dc.relation.citationissue24
dc.publisher.facultyFacultad de Ciencias Básicas
dc.affiliationSuárez-Barrera, M.O., Facultad de Ciencias Médicas y de la Salud, Instituto de Investigación Masira, Universidad de Santander, Bucaramanga, 680003, Colombia, Corporación de Ciencias Básicas Biomédicas, Universidad de Antioquia, Medellín, 050010, Colombia, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, 9700 RB, Netherlands, MaxPlanck Tandem Group in Nanobioengieneering, Institute of Chemistry, Faculty of Natural and Exact Sciences, University of Antioquia, Medellin, 050010, Colombia
dc.affiliationVisser, L., Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, 9700 RB, Netherlands
dc.affiliationRondón-Villarreal, P., Facultad de Ciencias Médicas y de la Salud, Instituto de Investigación Masira, Universidad de Santander, Bucaramanga, 680003, Colombia
dc.affiliationHerrera-Pineda, D.F., Facultad de Ciencias Médicas y de la Salud, Instituto de Investigación Masira, Universidad de Santander, Bucaramanga, 680003, Colombia
dc.affiliationAlarcón-Aldana, J.S., Facultad de Ciencias Médicas y de la Salud, Instituto de Investigación Masira, Universidad de Santander, Bucaramanga, 680003, Colombia
dc.affiliationVan den Berg, A., Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, 9700 RB, Netherlands
dc.affiliationOrozco, J., MaxPlanck Tandem Group in Nanobioengieneering, Institute of Chemistry, Faculty of Natural and Exact Sciences, University of Antioquia, Medellin, 050010, Colombia
dc.affiliationPinzón-Reyes, E.H., Facultad de Ciencias Médicas y de la Salud, Instituto de Investigación Masira, Universidad de Santander, Bucaramanga, 680003, Colombia
dc.affiliationMoreno, E., Facultad de Ciencias Básicas, Universidad de Medellín, Medellín, 050030, Colombia
dc.affiliationRueda-Forero, N.J., Facultad de Ciencias Médicas y de la Salud, Instituto de Investigación Masira, Universidad de Santander, Bucaramanga, 680003, Colombia
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