This article proposes a governance approach for the prioritization of sustainable development goals (SDGs) in the city of Medellín (Colombia, South America). The governance approach proposed in this study stems from the articulation of technical and participatory approaches. The technical approach took as reference the document CONPES 3918, which defines the national sustainable development agenda in Colombia. The participatory approach was supported by the Medellín Citizen Perception Survey, which reflects the most important aspects of the quality of life for citizens. The results indicate that priorities for sustainable development in Medellín should be oriented to SDG 17, SDG 3, SDG 8, SDG 5, and SDG 4. The consistency test (CR) indicates the instrument applied is consistent. © 2021 Editora CHAMPAGNAT. All rights reserved.