Introduction: Gynecological cancer impacts women psychologically. In this process, the Coping Strategies-CS are apparently associated with Health-Related Quality of Life HRQL; however, the predictive value of CS on HRQL is unknown. This article aims to identify the differences and the nature of the relationship of HRQL and CS regarding psychological support, as well as to identify whether CS predict HRQL. Method: A non-experimental design was performed with 55 women between 27 and 69 years old, M = 42.3, DE = 10.1, diagnosed with gynecological cancer. The HRQL was evaluated with the FACT-Cx and the SF-36; and the CS, with CAEPO (Spanish acronym). Results: Women with psychological support have better HRQL and CS, likewise, HRQL was correlated with positive CS. The general health dimension is also explained by positive CS, and inversely by negative CS. The CS that best predict HRQL are: active confrontation and fighting, and self-control and emotional control, while negative CS affect HRQL. Conclusion: The results highlight the need for psychological support that promotes positive CS and benefits HRQL in women with gynecological cancer. © 2021 Fundación Universitaria Konrad Lorenz.