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NbThermo: a new thermostability database for nanobodies
dc.contributor.author | Valdés-Tresanco M.S | |
dc.contributor.author | Valdés-Tresanco M.E | |
dc.contributor.author | Molina-Abad E | |
dc.contributor.author | Moreno E. | |
dc.date.accessioned | 2023-10-24T19:24:23Z | |
dc.date.available | 2023-10-24T19:24:23Z | |
dc.date.created | 2023 | |
dc.identifier.issn | 17580463 | |
dc.identifier.uri | http://hdl.handle.net/11407/7942 | |
dc.description.abstract | We present NbThermo-a first-in-class database that collects melting temperatures (Tm), amino acid sequences and several other categories of useful data for hundreds of nanobodies (Nbs), compiled from an extensive literature search. This so-far unique database currently contains up-to-date, manually curated data for 564 Nbs. It represents a contribution to efforts aimed at developing new algorithms for reliable Tm prediction to assist Nb engineering for a wide range of applications of these unique biomolecules. Nbs from the two most common source organisms-llama and camel-show similar distributions of melting temperatures. A first exploratory research that takes advantage of this large data collection evidences that understanding the structural bases of Nb thermostability is a complex task, since there are no apparent differences in sequence patterns between the frameworks of Nbs with lower and higher melting temperatures, indicating that the highly variable loops play a relevant role in defining Nb thermostability. Database URL https://valdes-tresanco-ms.github.io/NbThermo. © The Author(s) 2023. Published by Oxford University Press. | eng |
dc.language.iso | eng | |
dc.publisher | NLM (Medline) | |
dc.relation.isversionof | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85152277181&doi=10.1093%2fdatabase%2fbaad021&partnerID=40&md5=68e8bf68a5b32b851c0d73de1511d8a3 | |
dc.source | Database (Oxford) | |
dc.source | Database : the journal of biological databases and curation | eng |
dc.title | NbThermo: a new thermostability database for nanobodies | eng |
dc.type | Article | |
dc.rights.accessrights | info:eu-repo/semantics/restrictedAccess | |
dc.publisher.program | Ciencias Básicas | spa |
dc.type.spa | Artículo | |
dc.identifier.doi | 10.1093/database/baad021 | |
dc.relation.citationvolume | 2023 | |
dc.publisher.faculty | Facultad de Ciencias Básicas | spa |
dc.affiliation | Valdés-Tresanco, M.S., Faculty of Basic Sciences, University of Medellin, Cra. 87 No. 30-65, Medellin, 050026, Colombia | |
dc.affiliation | Valdés-Tresanco, M.E., Centre for Molecular Simulations and Department of Biological Sciences, University of Calgary, 2500 University Drive N.W, Calgary, AB T2N 1N4, Canada | |
dc.affiliation | Molina-Abad, E., Medellin, 050021, Colombia | |
dc.affiliation | Moreno, E., Faculty of Basic Sciences, University of Medellin, Cra. 87 No. 30-65, Medellin, 050026, Colombia | |
dc.type.version | info:eu-repo/semantics/publishedVersion | |
dc.identifier.reponame | reponame:Repositorio Institucional Universidad de Medellín | |
dc.identifier.repourl | repourl:https://repository.udem.edu.co/ | |
dc.identifier.instname | instname:Universidad de Medellín |
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