In this work, we analyze quantum decoherence in neutrino oscillations considering the open quantum system framework and oscillations through matter for three-neutrino families. Taking the Deep Underground Neutrino Experiment as a case study, we performed sensitivity analyses for two neutrino flux configurations, finding sensitivity limits for the decoherence parameters. We also offer a physical interpretation for a new peak which arises at the ?e appearance probability with decoherence. The sensitivity limits found for the decoherence parameters are ?21?1.2×10-23 GeV and ?32?7.7×10-25 GeV at 90% C.L. © 2019 authors.